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**CancerParticipant.avdl**
* Major Changes:
- `PreservationMethod`, `GelPhase` terms to upper case
- `Sex` in `CancerParticipant` is defined now as `{M,F}`
- Added `VersionControl` to `CancerSample` and `CancerDemographics`
- Added `center` and `centerPatientId` to `CancerDemographics`, both are required
* Minor Changes:
- `labId` and `sampleDiagnosis` in `CancerSample` can be null
- `germlineSampleId` and `tumorSampleId` in `MatchedSamples` can be null
- `primaryDiagnosis`, `sampleId` and `sex` can be null in `CancerDemographics`
- Added `assignedICD10` to `CancerDemographics`
**GelBamMetrics.avdl**
* Major changes:
- `PURITY_TUMOR_PLOIDY` and `PURITY_TUMOR_PURITY` are now double and, they can be null
- Added `InsertSizeGel` (new record)