v0.5.0 marks a major overhaul of the Cell BLAST code base, where obsolete dependencies and have been replaced by modern solutions. Meanwhile, care has been taken to ensure that the new implementation has the same high-level API, and generates results consistent with the old one.
Major changes include:
1. Switched model backend from the old Tensorflow v1 to [PyTorch](https://pytorch.org/);
2. Ditched in-house data class and file format in favor of [AnnData](https://anndata.readthedocs.io/en/latest/).
See our [migration guide](https://cblast.readthedocs.io/en/latest/migration.html) for details on any necessary change to existing code and data utilizing `Cell BLAST`.